Endocrine Abstracts

The current conventional glucocorticoid (GC) replacement therapy in primary adrenal insufficiency (Addison’s disease) and congenital adrenal hyperplasia (CAH) renders the cortisol levels unphysiological, resulting in very high levels alternating with almost undetectable levels of cortisol over the day. This reduces not merely the patient’s quality of life but increases the patient’s morbidity and mortality. The HPA axis is characterised by a dynamic circadian va...

Background: In subjects with long duration of type 2 diabetes (T2DM), strict glycaemic control fails to decrease the incidence of cardiovascular disease (CVD). Impaired vascular indices have been associated with adverse cardiovascular prognosis in T2DM. We examined whether intensive glycaemic control in T2DM patients improves vascular indices.Methods: We studied 68 T2DM patients (64±9 years, 52% males, and T2DM duration 14±10 years) with poor g...

Introduction: Urinary iodine concentration (UIC) can reflex recent changes in iodine status and serve as a sensitive marker of current iodine intake. The cut-off value of UIC was determined as the level lower than 100 μg/l. Adequate median urinary iodine for iodine intake in pregnancy is 150–249 μg/l. The aim of this study was to map the situation of iodine intake in pregnant women with pregestational and gestational diabetes and to explore relationship with thy...

Objectives: Patients with thyroid dysfunction due to AITD have been found to have increased oxidative stress. Possible associations of oxidative stress with thyroid hormone (TH) and thyroid autoantibodies (ThAb) levels in euthyroid patients with autoimmune thyroiditis have not been adequately studied. We examined possible associations of oxidative stress markers with TH levels and with the presence of ThAb in euthyroid women with Hashimoto’s thyroiditis (with or without T...

Objectives: In familial MTC there is genotype-phenotype correlation. The phenotype and clinical outcome in exon8 (G533C) carriers has not been well established.Methods: 95 patients operated for familial MTC (27.2% males) were followed for 0.9–30 years (mean 8.0, median 5.5 years). 45.3% (n=43) were exon8 carriers (exon8MTC) and the remaning were non-exon8MTCs (n=52, exons 10, 11, 13, 14, and 16). Pre-, postoperative calcitonin, ext...

Adipokine omentin is a connecting link between obesity and type 2 diabetes mellitus. It modulates insulin sensitivity of peripheral tissues and its secretion may change in the developed inflammation of adipose tissue at its excessive accumulation. Chemokine fractalkine is a marker of the development of inflammatory processes in the body. Objective: omentin and fractalkine contents in blood circulation depending on the degree if adipose tissue accumulation, waist circumference,...

Introduction: Salivary cortisol measurement, representing free cortisol, seems to be a promissing alternative method to serum cortisol. Besides its use in the diagnostics of hypercortisolism, it could be of help in evaluation of adrenocortical reserve. It might be useful especially in patients on estrogen replacement, which modulates transcortin and hence total cortisol levels.Aims: Compare the reliability of salivary vs. serum cortisol assessment during...

Introduction: Accident at the Chernobyl NPP (ChNPP) in Ukraine on the 26th of April, 1986 was followed by the intensive release of a wide range of radioactive elements with affinity to many endocrine tissues. The mentioned radioactive fallout resulted in both internal and external radiation exposure, among others, of the central endocrine structures of the human brain.Methods: We have conducted a retrospective analysis (20–25 years upon radiation ex...

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

Introduction: Recently, small medullary thyroid carcinomas (sMTCs) (≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical and autopsy specimens. Their clinical course varies. We examined whether tumor size is a predictor of clinical behavior.Patients and methods: One hundred and one sMTC patients (36.6% males, 47.1% familial) followed-up for 0.9–35 years. Patients were classified according to tumor size (cm) in gro...